The ability of future industry to create interactive, flexible and always-on connections between design, manufacturing and supply is an ongoing challenge, affecting competitiveness, efficiency and resourcing. The goal of enterprise interoperability (EI) research is therefore to address the effectiveness of solutions that will successfully prepare organizations for the advent and uptake of new technologies.
This volume outlines results and practical concepts from recent and ongoing European research studies in EI, and examines the results of research and discussions cultivated at the I-ESA 2018 conference, "Smart services and business impact of enterprise interoperability". The conference, designed to encourage collaboration between academic inquiry and real-world industry applications, addressed a number of advanced multidisciplinary topics including Industry 4.0, Big Data, the Internet of Things, Cloud computing, ontology, artificial intelligence, virtual reality and enterprise modelling for future "smart" manufacturing.
Readers will find this book to be a source of invaluable knowledge for enterprise architects in a range of industries and organizations.
This book is the first to be dedicated to the bioinformatics of carbohydrates and glycoproteins. It provides an introduction to this emerging field of science both for the experimentalist working in glycobiology and glycomics, and also for the computer scientist looking for background information for the development of highly sophisticated algorithmic approaches. The book provides an overview of the state-of-the-art in the field, with reviews on databases, and the tools in use for analysis, interpretation, and prediction of the structures of complex carbohydrates, and demonstrates the value of bioinformatics for glycobiology. The availability of comprehensive databases and corresponding bioinformatics tools, to access and analyse the large amounts of experimental data relating to the structure of carbohydrates, will be a prerequisite for the success of the large-scale glycomics projects that aim to decipher new, so far unknown, biological functions of glycans. Efficient bioinformatics descriptions and tools can considerably enhance the efficiency of glycomics research, in terms of data quality, analysis and experimental costs. For a complete understanding of the molecular processes in which carbohydrates are involved, such as protein-carbohydrate interactions and the impact of glycosylation on protein function, knowledge of the 3D structure of the carbohydrate, the protein-carbohydrate complex, or the glycoprotein is often indispensable. This book provides a thorough introduction into methods used for conformational analysis of carbohydrates. Key features: Describes bioinformatic approaches to handle carbohydrate-active enzymes and glycosylation. Provides an overview on bioinformatics tools that facilitate analysis of carbohydrate structures. Gives introduction into molecular modelling of carbohydrate 3D structure and carbohydrates contained in the Protein Databank. Assumes only a basic knowledge of biology and bioinformatics.
The proven strategies rational investors require for success in an irrational market When the dot-com and real estate bubbles of the 1990s and 2000s burst, few were spared the financial fallout. So, how did an investment advisory firm located in Elkhart, Indiana-one of the cities hit hardest by the economic downturns-not only survive, but also thrive during the highly contagious speculative pandemics. By remaining rational. In A Decade of Delusions: From Speculative Contagion to the Great Recession, Frank Martin founder of Elkhart, Indiana's Martin Capital Management offers a riveting and real-time insider's look at the two bubbles, and reflects on how investors can remain rational even when markets are anything but. Outlines strategies the average investor can use to wade through the endless news, information, and investment advice that bombards them Describes the epidemic of market speculation that gradually infects feverish investors Details how investors can spare themselves the emotional devastation and accompanying paralysis resulting from shocking financial losses Investors are still reeling from the instability in the market. A Decade of Delusions: From Speculative Contagion to the Great Recession provides the information investors need to achieve safety, liquidity, and yield.
Es gehrt zu den Aufgaben der medizinisch-wissenschaftlichen Fachgesellschaften, Leitlinien zu entwickeln und ihren Praxistransfer zu gewährleisten. Leitlinien beruhen auf empirischer Evidenz und Expertenkonsens und sollen den praktisch Tätigen dazu dienen, Diagnostik und Therapie nach dem aktuellen Stand der Wissenschaft zu gestalten. Leitlinien sind an den jeweiligen Stand der Wissenschaft angepasst und geben einen evidenzbasierten Handlungsrahmen vor.Nach einem systematischen Revisionsprozess stellt die aktuelle S3- bzw. Nationale VersorgungsLeitlinie das aktuell verfügbare Wissen zur Erkennung, Diagnose und Therapie sowie Nachsorge von unipolaren Depressionen dar. Sie formuliert auf über 250 Seiten mehr als 120 Schlüsselempfehlungen und ersetzt die alte Leitlinie, die 2009 erstmals verffentlicht wurde. Die Leitlinie richtet sich an alle Berufsgruppen, die ambulant und stationär Patienten mit Depressionen behandeln. Für Betroffene und Angehrige wurde zusätzlich eine eigenePatientenleitlinie entwickelt.
This volume illustrates the continuous arms race between attackers and defenders of the Web ecosystem by discussing a wide variety of attacks. In the first part of the book, the foundation of the Web ecosystem is briefly recapped and discussed. Based on this model, the assets of the Web ecosystem are identified, and the set of capabilities an attacker may have are enumerated. In the second part, an overview of the web security vulnerability landscape is constructed. Included are selections of the most representative attack techniques reported in great detail. In addition to descriptions of the most common mitigation techniques, this primer also surveys the research and standardization activities related to each of the attack techniques, and gives insights into the prevalence of those very attacks. Moreover, the book provides practitioners a set of best practices to gradually improve the security of their web-enabled services. Primer on Client-Side Web Security expresses insights into the future of web application security. It points out the challenges of securing the Web platform, opportunities for future research, and trends toward improving Web security.
20 years ago, from July 8 to 20, 1990, 60 researchers gathered for two weeks at Castillo-Palacio Magalia in Las Navas del Marques (Avila Province, Spain) to discuss cognitive and linguistic aspects of geographic space. This meeting was the start of successful research on cognitive issues in geographic information science, produced an edited book (D. M. Mark and A. U. Frank, Eds., 1991, Cognitive and Linguistic Aspects of Geographic Space. NATO ASI Series D: Behavioural and Social Sciences 63. Kluwer, Dordrecht/Boston/London), and led to a biannual conference (COSIT), a refereed journal (Spatial Cognition and Computation), and a substantial and still growing research community.
It appeared worthwhile to assess the achievements and to reconsider the research challenges twenty years later. What has changed in the age of computational ontologies and cyber-infrastructures? Consider that 1990 the web was only about to emerge and the very first laptops had just appeared! The 2010 meeting brought together many of the original participants, but was also open to others, and invited contributions from all who are researching these topics. Early-career scientists, engineers, and humanists working at the intersection of cognitive science and geographic information science were invited to help with the re-assessment of research needs and approaches.
The meeting was very successful and compared the research agenda laid out in the 1990 book with achievements over the past twenty years and then turned to the future: What are the challenges today? What are worthwhile goals for basic research? What can be achieved in the next 20 years? What are the lessons learned?
This edited book will assess the current state of the field through chapters by participants in the 1990 and 2010 meetings and will also document an interdisciplinary research agenda for the future.
Multimedia networking applications and, in particular, the transport of c- pressed video are expected to contribute signi?cantly to the tra?c in the future Internet and wireless networks. For transport over networks, video is typically encoded (i. e. , compressed) to reduce the bandwidth requirements. Even compressed video, however, requires large bandwidths of the order of hundred kbps or Mbps. In addition, compressed video streams typically - hibit highly variable bit rates (VBR) as well as long range dependence (LRD) properties. This, in conjunction with the stringent Quality of Service (QoS) requirements (loss and delay) of video tra?c, makes the transport of video tra?covercommunicationnetworksachallengingproblem. Asaconsequence, in the last decade the networking research community has witnessed an - plosion in research on all aspects of video transport. The characteristics of video tra?c, video tra?c modeling, as well as protocols and mechanisms for the e?cient transport of video streams, have received a great deal of interest among networking researchers and network operators and a plethora of video transport schemes have been developed. For developing and evaluating video transport mechanisms and for - search on video networking in general, it is necessary to have available some characterizationofthevideo. Generally,therearethreedi?erentwaystoch- acterize encoded video for the purpose of networking research: (i)video tra?c model,(ii) video bit stream, and (iii) video tra?c trace.
Der Morbus Dupuytren beschreibt eine fibroproliferative Erkrankung der Hohlhandaponeurose mit Teilen des subkutanen Fasersystems an Hohlhand und Fingern und stellt als multifaktorielle Erkrankung mit erblicher Veranlagung und Hang zum Rezidiv für den behandelnden Arzt eine therapeutische Herausforderung dar. Es handelt sich dabei vorwiegend um eine Erkrankung des älteren Menschen, die hauptsächlich in Nordeuropa auftritt. Zur Behandlung der Dupuytren-Kontraktur haben sich neben der minimal invasiven perkutanen Nadelaponeurotomie, vor allem die partielle Aponeurektomie als chirurgisches Verfahren durchgesetzt. Weitere Therapieverfahren sowie die Besonderheiten bei der operativen Therapie einer Rezidiv-Kontraktur werden ausführlich dargestellt.
Um ein neues Kapitel in der Forschungsgeschichte zu Musik und Religion aufschlagen zu knnen, sollte wohl auf überholte Unterscheidungen (etwa von sakraler und profaner Musik) oder auf vereinfachende Gegenüberstellungen (etwa von wertvoll-ernster, geistreicher Musik und minderwertig-heiterer, niveaulos-trivialer Musik) verzichtet werden: Die in vorliegendem Band gesammelten Beiträge orientieren sich folgerichtig an einem reichen Bündel geschichtsträchtiger und alltagsrelevanter Kulturphänomene, die sensibel wahrgenommen, sorgfältig reflektiert und diskursiv erschlossen werden wollen. In dieses Konzert vieler Stimmen werden Begriffe und Konzepte von Tonkunst und Klangdichtung, Harmonie und Melodie, Rhythmus und Metrik, Schall und Stimme, Eindruck und Ausdruck, Komposition und Produktion, Genuss und Gestaltung, Gefühl und Logik, Leib und Seele eingespielt, auf dass der Geist zwischen Musik und Religion als Spirit und als Spiritus spürbar werde.
Das interdisziplinäre Grundlagenwerk informiert aus der Perspektive von Neurologie, Rehabilitation, Ingenieurwesen, Pädagogik und Physiotherapie sowie aus Sicht der Patienten über Mglichkeiten und Grenzen des Einsatzes von Technik, um die Teilhabe neurologisch erkrankter Menschen zu verbessern. Ziel des Buches ist, allen Berufsgruppen, die an der Behandlung schwer und komplex erkrankter neurologischer Patienten beteiligt sind, ein umfassendes Verständnis assistiver und rehabilitativer Technologien zu vermitteln.
